Relação dos níveis séricos de vitamina b12 em pacientes com supercrescimento bacteriano intestinal após gastroplastia com derivação intestinal em Y de ROUX

Abstract

Bariatric surgery is a secondary surgical treatment indicated when other clinical treatments have not been successful. The most used technique in Brazil is Roux-en-Y Intestinal Bypass Gastroplasty. The anatomical and physiological changes promoted by bariatric surgery can trigger an imbalance in the intestinal microbiota causing Small Intestinal Bacterial Overgrowth (SIBO) and nutritional deficiencies. The aim of the present study was to analyze whether there are vitamin B12 deficiencies related to SIBO after bariatric surgery. For the present research, the qualitative-quantitative method of a descriptive nature was used, where data analysis was carried out by correlation and linear regression (Pearson's test) to assess the link between those two variables. This research is partialy based on the research project entitled “Effect of probiotics on intestinal microbiota and on nutritional, biochemical and clinical indicators after Roux-en-Y gastric bypass” approved by UFPR. The data used refer to the placebo group. In total, the sample consisted of 18 participants with a confirmed diagnosis of SIBO through the hydrogen breath test. According to the Person correlation test, there is a weak correlation between the presence of SIBO and the serum levels of vitamin B12 in the analyzed sample (r = -0.17; p = 0.50). In the literature, there are no previous clinical studies on the presented topic. Therewith, there is a need for more clinical studies comparing cobalamin levels in post-bariatric patients with SIBO, in order to obtain more specific and comparative data.