Métodos regenerativos usando plasma rico em fibrina como opção terapêutica. Revisão de literatura

Abstract

Over the years, the different types of platelet aggregation have been gaining more space in both the dental and medical fields. In the early days, platelet-rich plasma (PRP) was often used but became obsolete, and was replaced by fibrin-rich plasma (FRP), where it has been often used to repair and regenerate bone defects, making this process faster and more effective compared to other regenerative techniques. With the rapid evolution of these aggregations in the last 20 years, these autologous products have become more accessible, reliable and cheaper. Thus, the objective of this literature review is to highlight the evolution of platelet aggregates, in which hypotheses and in what ways they can be used, adding new information about the addressed subject given the advances and changes that have occurred over time. According to researchers there are two generations of platelet aggregates: the first one, in which PRP is inserted, and the second generation, in which FRP is inserted along with leukocyte-platelet rich fibrin (L-PRF). The aggregations from the second generation have a more flexible fibrin mesh, in addition to providing greater osteogenic, angiogenic and antimicrobial activity, an immunology of the healing process is optimized by the various growth factors released by these products. Thus, the expected result in terms of procurement protocols is a non-rigid three-dimensional mesh, which is suitable for various defects, situations and tissues. Therefore, tissue regeneration using a technique with PRF has been considered promising and constantly used in the daily lives of dentists and other health professionals because it is a simple technique, easy to obtain and does not provide any type of rejection, being it an autogenous product of the patient. Thus, by means of such attributions, the PRF is used today throughout the world.