Superalimentação na lactação programa alterações metabólicas ao desmame em ratos machos Wistar

Abstract

It is well known in the literature the importance of nutrition during childhood, and that it has consequences that lasts until adulthood through metabolic programming. The objective of our work was to evaluate the effects caused by overfeeding during suckling period on the infant's physiology. For that, we evaluated male rats on small litter models, to simulate an overfeeding in the reduced litters. The rats were raised under controlled environment and weighted every two days, been euthanized on day 21, considered the weaning day. The weight of pups was measured, and the main fat pad stores, as well as the liver, were collected for weighting and evaluation of the biometric parameters. Blood from the pups and milk from the dams were also collected for biochemical analysis. The overfeeding animals developed increase in total weight, as well as a large increase in their main fat pad stores. In addition to heavy weight, they presented dyslipidemia with increased levels of total cholesterol and triglycerides, causing metabolic dysfunction. The results prove the importance of a healthy diet early in life, in order to avoid future health complications.