Avaliação do padrão de recorrência tumoral relacionada ao diagnóstico molecular em mulheres com câncer de mama: revisão sistemática

Abstract

Breast cancer is a disease with high prevalence among women, which, as a result, causes great economic and social impact. In this context, despite advances in the therapeutic approach, cases of recurrence may still occur. These are characterized by evidence through symptoms or imaging tests of the return of the neoplasm after treatment and are closely related to the heterogeneous characteristics of this type of cancer and the therapeutic failure. Thus, the present study aims to assess factors related to the recurrence of breast neoplasms through a literature review. Five PUBMED articles published during the period of 2015-2020 were selected through specific descriptors and the Delphi List classified the methodology as adequate. Through the analysis of these articles, it has been found that the subtypes most related to recurrence are HER2 and triple negative (TN). On the other hand, those with the lowest indexes are luminal type A and B. Another important point, is that the complete pathological response would have a positive prognostic value, just as the occurrence of early metastasis would be related to a less aggressive pattern. Regarding the patient’s intrinsic factors, age was not considered a prognostic factor for recurrence