A inibição da via da fosfatidilinositol 3-quinase (PI-3K) como estratégia terapêutica no tratamento oncológico

Abstract

The PI3K intracellular signaling pathway has been extensively studied to find ways to inhibit it pharmacologically. That's because in some cancers, its continued activation triggers a series of receptors involved in cell growth, differentiation, maturation and proliferation. As such, it is crucial for the overall development of a patient's tumor process and for various changes in tumor metabolism involving numerous cellular proteins. These changes are aimed at improving energy supply and products synthesized by cells. In this study, through a comprehensive literature review, we will bring together the most concise and specific information obtained from indexing platforms such as PubMed and Google Scholar. We will focus on the involvement of PI3K signaling in tumor pathogenesis and pharmacological intervention using PI3K inhibitors.